• ANTIDEPRESSANT ACTIVITY OF Spirulina Platensis IN EXPERIMENTALLY INDUCED DEPRESSED MICE

Suresh D, Madhu M, Saritha Ch, , Raj kumar V, Shankaraiah P*

Abstract


The spray dried powder of Spirulina platensis was used to treatment of depression in different doses (100mg/kg, 200 mg/kg and 400 mg/kg) and Impramine (15mg/kg) as standard drug in experimental animal models like Forced swim test in mice, Tail suspension test in mice, Clonidine induced aggression behaviour in mice test, L-dopa induced hyper activity and aggressive behavior in mice, 5-HT induced head twitches in mice, From all the experimental model results were observed that the Spirulina platensis was possess the dose dependent anti depressant activity.


Keywords


Spirulina platensis , Depression, Imipramine, 5-HT, L-dopa, Clonidine.

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