• SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1, 6-DIHYDRO PYRIDINE DERIVATIVES

YADAV ANITA*, MAGDUM C. S.

Abstract


The 2-amino-4-ethyl-1,6-dihydro 6-thiophenyl pyridine-3,5- dicarbonitriles were synthesized within a single step using aldehydes, active methylene compounds and thiophenol in ethanol and piperidine system. The synthetic potential of the method was to be investigated to obtain its 4-substituted and 6-substituted derivatives. In view of this the prior method was optimized and the desired 4-sustituted and 6-substituted compounds were synthesized with 60-90% yield. Newly synthesized compounds were found to have antifungal and antihistaminic activity.


Keywords


Aspergillus niger, Candida albicans, cinnamonitriles, DHP, thiophenol Derivatives.

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