• IMPACT OF SUBLETHAL CONCENTRATION OF POTASSIUM DICHROMATE ON BIOCHEMICAL FACTORS OF ALBINO WISTAR RAT

Abstract

The chemical and related industries occupy a key position in the economic life of a nation. The chemical industry supplies a vast range of products which find their way in to a wide spectrum of human activity. Many of these chemical when present in the environment are potentially hazardous.  Some being explosive some inflammable, some toxic and yet some others corrosive etc. Adverse effect of chromium are mainly associated with hexavalent from which are highly toxic to humans. Inhalation exposure to the insoluble chromium (IV) results in the retention of metals inside lungs for long period of time. Exposure to hexavalent chromium causes dermatitis allergic skin reaction, respiratory diseases and gastro – intestinal ulcers. In the present  investigation the biochemical factors namely, total protein, free amino acids, total lipids and free fatty acid were estimated  as per the standard methods  as follows in various tissue such as brain, kidney, muscle and liver of  albino wistar  rats exposed to sublethal concentration of potassium dichromate to the duration of 15, 20 and 30 days. The results show all the biochemical factors values of total protein increased gradually from less to longer duration. Whereas the free amino acids gradually decreased. The total lipids are gradually increased the free fatty acid are gradually increased. The values are statistically significant.