• SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 5, 5-DIPHENYL N (3)-SUBSTITUTED IMIDAZOLIDINE 2, 4-DIONE DERIVATIVES

P. Nihar*, V. Shankarananth, M. Padmavathamma, Y. Kalyani, K. K. Rajasekhar, D. Ranaganayakulu

Abstract


A Convenient high yield synthesis of pharmaceutically interesting 5,5-diphenyl N(3)-substituted imidazolidine 2,4-dione derivatives from benzil  and urea is described. The structures of compounds were established on the basis of IR,NMR and GC-MS  spectral data. The title compounds were investigated for anti-inflammatory and antibacterial activity. The tested compounds exhibited good antiinflammtory and antibacterial activity as compared to standard drugs. The 5,5-diphenyl imidazolidine dione was generated from the condensation between benzil and urea and then converted to the desired  derivatives by condensation with aryl compounds.


Keywords


Synthesis, benzil, urea, sodium hydroxide, aryl compounds, anti-inflammatory and antibacterial activity.

Full Text:

PDF

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
© 2012-2020 IJPA 
Copyright Agreement & Authorship Responsibility
Hit Counters