• SYNTHESIS, DOCKING AND ANTIMICROBIAL ACTIVITY OF TRANSITION METAL COMPLEXES OF PHENYLHYDRAZONES

VARADARASSOU MOUTTAYA MOUNNISSAMY*, JARINA ABDUL, EZHILARASI GANGATHARAN

Abstract


Zinc complexes have been prepared by reacting metal chloride with ortho chlorobenzaldehyde phenylhydrazone and para dimethyl aminobenzaldehyde phenylhydrazone. Docking study has been carried out for prepared complexes by using autodock software against Biotin Carboxylase (3JZI) as a target protein. The antimicrobial activity have been studied and compared with their ligands against Stapylococcus aureus, Bacillus substilis, Escherichia coli, Salmonilla paratyphi, Candida albicans, Aspergillus fumigates which gave significant results of activity.


Keywords


Synthesis, Transition metal complex, Phenylhydrazone, Antibacterial, Antifungal activity, Antimicrobial activity.

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