• Synthesis and Antitubercular activity of Some Oxazolidine Dione Derivatives

Abstract

A Convenient high yield one pot methodology for the synthesis of pharmaceutically interesting oxazolidine-2, 4-dione derivatives from α-hydroxy esters is described. The structures of compounds were established on the basis of IR and NMR spectral data. The title compounds were investigated for antitubercular activity. The tested compounds exhibited good antitubercular activity as compared to standard drug. The oxazolidine-2,4 dione was generated from the condensation between α-hydroxy ester and guanidine and then converted to the desired derivatives via aqueous acid hydrolysis, alkylation with different alkyl halides.